Our Technology
GenoConnect uses Whole Genome Sequencing (WGS) — the most comprehensive DNA analysis technology available. The depth of your results depends on the sequencing tier you choose.
What is Whole Genome Sequencing?
Whole Genome Sequencing (WGS) reads the complete sequence of your DNA — all ~3.2 billion base pairs across every chromosome. Unlike older SNP genotyping approaches that only look at a pre-selected set of known positions in the genome, WGS scans the entire genetic code, uncovering both common and rare variants, structural changes, and novel mutations that targeted arrays would miss entirely.
The critical variable in WGS is sequencing depth (coverage) — how many times each position in the genome is independently read. Greater depth means more confidence in every variant call and more rare variants discovered. GenoConnect offers four tiers, from an accessible 1× standard up to the 30× gold standard used in hospitals.
Full Genome
Reads all 3.2 billion base pairs — not just selected markers
Coverage Depth
Higher coverage = more reads per position = greater accuracy
Rare Variants
Detects common, rare, and novel variants missed by genotyping chips
Choose Your Sequencing Depth
All tiers use the same physical kit and sample collection process. The difference is entirely in how your sample is processed in the lab — more coverage means deeper insight and higher confidence.
Standard 1x WGS
Our baseline test reads your entire genome at 1× coverage — all 3 billion base pairs. It delivers broad insights into your ancestry, common trait variants, and known health predispositions at an accessible price point.
- Full genome scan
- Ancestry & heritage
- Common trait & wellness variants
- ~95% genome coverage
Enhanced Discovery 5x WGS
5× coverage means each base in your genome is read an average of five times, dramatically improving confidence in variant calls. Detects significantly more rare and low-frequency variants than 1× sequencing.
- 5× more data than standard
- Deeper rare-variant discovery
- Greater result confidence
- Richer trait & health insights
Clinical Grade 5x WGS + 100x WES
Combines 5× whole-genome coverage with ultra-deep 100× exome sequencing. The exome (protein-coding regions, ~1–2% of the genome) is the most medically relevant part of your DNA — 100× depth enables high-confidence clinical variant detection.
- 5× whole genome + 100× exome
- Clinical-grade exome analysis
- Rare disease variant detection
- Ideal for health-focused users
Premium 15x WGS
15× coverage delivers clinical-grade depth across your entire genome. Every position is read ~15 times, providing high-confidence variant calls for SNPs, indels, and structural variants — meeting standards used by clinical and research institutions at the best premium value price point.
- Clinical-grade depth
- High-confidence variant calling
- Detects structural variants
- Best value premium tier
Hospital Grade 30x WGS
30× coverage is the standard used by hospitals, research institutions, and clinical genetics labs worldwide. Every position in your genome is read ~30 times, providing the highest confidence variant calls and detecting even the rarest variants.
- Hospital & research standard
- Highest variant-call accuracy
- Detects structural variants
- Maximum genome insight
Coverage Depth and Result Accuracy
The accuracy and completeness of your genetic results are directly tied to the sequencing depth you choose. Here is how coverage depth translates to real-world quality:
| Test | Coverage | Variants Detected | Best For |
|---|---|---|---|
| Standard 1x WGS | 1× | Common variants, broad genome scan | Ancestry, traits, wellness |
| Enhanced 5x WGS | 5× | Common + rare variants, higher confidence | Deeper health & trait analysis |
| Clinical Hybrid 5x+100x WES | 5× WGS + 100× exome | All variants + clinical-grade exome | Medical & clinical applications |
| Premium 15x WGS | 15× | All variants including structural, high confidence | Clinical, research — best value premium |
| Hospital Grade 30x WGS | 30× | All variants including structural, highest accuracy | Research, clinical, maximum precision |